sNK Cells: More Potent | More Robust

NK101: The Benefits of NK Cells


  • Less toxic, more potent cellular therapy for the treatment of cancer patients and other immune system disorders

  • The “off-the-shelf” (cryopreserved, allogeneic) nature of the therapy allows global access to a cutting-edge therapeutic

  • Based on preclinical results, potential for lasting remission

  • Works to restore NK cell function while expanding patient’s own T-cells, & immune function

  • Therapeutic potential expandable in many types of cancers & other immune system disorders


Mechanisms Involved in sNKs Cell-Mediated Reversal or Eradication of Tumor

Supercharged NK Cells Induce Disease Reversal


sNK cells are a type of immune cell that can destroy cancer cells directly and help them become less aggressive. They also boost the activity of other immune cells, like CD8+ T cells, which are powerful cancer fighters. sNK cells improve the immune system’s ability to work in different parts of the body, increase the number of immune cells in tumors, and enhance their ability to attack cancer. Together, these actions either kill the cancer cells directly or help the immune system stop or reverse the disease. This shows how important sNK cells are in fighting cancer effectively.

sNK Cells: More Potent | More Robust

Functional Characteristics

of sNK Cells

  • In-vitro and in-vivo studies have demonstrated that sNK cells increased the number of cytotoxic CD8+ T cells. These T cell subsets play a crucial role in destroying differentiated cancers.


  • Several studies have demonstrated defects or reduced anti-cancer function in immune cells in cancer patients. In our in-vivo humanized mice cancer models, a single infusion of sNK cells restored 60-90% of the immune cell function, and both cytotoxic function and cytokine secretion was restored in the spleen, peripheral blood, gingiva, pancreas, and bone marrow. These sNK cells activated immune cells and play a role in tumor eradication and reversal.

  • sNK cells released significantly higher levels of cytokines. Especially those playing a role in tumor differentiation. Differentiated tumors growat a low rate, metastasize less, and are favorable targets of CD8+ T cells, checkpoint inhibitors, chemotherapy drugs, etc.


  • Our in-vivo studies in several cancer models have demonstrated that a single infusion of sNKs resulted in 9 fold increased infiltration of immune cells in tumors. These tumor-infiltrated immune cells play a role in tumor eradication and reversal.


  • sNK cells induced direct cytotoxicity and ADCC in cancer. We found that sNK cells compared to other activated NK cells induced significantly higher cytotoxicity suggesting sNK cells are much more effective in eradicating cancer.